196 research outputs found

    Going Global: GIS Day(s) 2020

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    GIS Day, a traditional drop-in and interactive event to promote and celebrate geospatial technology, is recognized by most if not all OCUL institutions. This year, the event went digital, thanks to Western University Library and several OCUL institututions, organizations, and over 30 volunteers, and 47 presenters.  This article summarizes the planning, delivery and execution of this event.  &nbsp

    Administration of the antioxidant n-acetyl-cysteine in pregnant mice has long-term positive effects on metabolic and behavioral endpoints of male and female offspring prenatally exposed to a high-fat diet

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    A growing body of evidence suggests the consumption of high-fat diet (HFD) during pregnancy to model maternal obesity and the associated increase in oxidative stress (OS), might act as powerful prenatal stressors, leading to adult stress-related metabolic or behavioral disorders. We hypothesized that administration of antioxidants throughout gestation might counteract the negative effects of prenatal exposure to metabolic challenges (maternal HFD feeding during pregnancy) on the developing fetus. In this study, female C57BL/6J mice were fed HFD for 13 weeks (from 5-weeks of age until delivery) and were exposed to the N-acetyl-cysteine (NAC) antioxidant from 10-weeks of age until right before delivery. Body weight of the offspring was assessed following birth, up to weaning and at adulthood. The metabolic, neuroendocrine and emotional profile of the adult offspring was tested at 3-months of age. Prenatal HFD increased mother’s body weight and offspring’s weight at the time of weaning, when administered in conjunction with NAC. In females, NAC administration reduced high levels of leptin resulting from prenatal HFD. Prenatal NAC administration also resulted in greater glucose tolerance and insulin sensitivity while increasing adiponectin levels, as well as increasing exploratory behavior, an effect accompanied by reduced plasma corticosterone levels in response to restraint stress. Analysis of glutathione levels in the hypothalamus and in brown adipose tissue indicates that, while HFD administration to pregnant dams led to reduced levels of glutathione in the offspring, as in the male hypothalamus, NAC was able to revert this effect and to increase glutathione levels both in the periphery (Brown Adipose Tissue, both males and females) and in the central nervous system (males). Overall, results from this study indicate that the body redox milieu should be tightly regulated during fetal life and that buffering OS during pregnancy can have important long-term consequences on metabolic and behavioral endpoints

    Investigation of Saudi Teachers’ Perceptions of Teaching and Learning after a 12-month Professional Development Programme in Australia

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    This study investigates the perceptions of teaching and learning of teachers from Saudi Arabia who participated in a 12-month professional development programme based in Australia. Considering the design of the programme and the vast differences between the education systems and cultures of the two countries, this study examines Saudi teachers’ classroom practices and challenges while teaching at schools in their home country, and whether their perceptions of teaching practice changed during and after participating in the professional development programme in Australia. Factors that might have influenced the changes to and nature of their teaching aspirations and plans for their students and schools in Saudi Arabia are also discussed

    Customer Referral Behavior: Do Switchers and Stayers Differ?

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    In today’s highly competitive market environment, service providers are beginning to recognize that customer referral plays an important role in enhancing firm value through cost-effective acquisition of new customers. While a significant body of research has focused on exploring customer referral, surprisingly limited research to date has addressed how customer referral may vary for different customer groups, particularly among switchers and stayers. This article examines the moderating effect of switchers and stayers on the relationships between service quality and perceived value on customer referral behavior. Actual referral data were collected from 441 customers of an Internet Service Provider in two waves for this study. The results show that the effects of positive changes in service quality and perceived value on customer referral behavior are stronger for recently acquired customers (switchers) than for long-term customers (stayers). The findings of the study suggest that investment in service quality and value improvements yield significantly higher returns (through greater customer referrals) for switchers than for stayers. Based on the findings, the authors recommend that service managers should identify and target newly acquired customers, who have switched from different service providers, right from the outset of the relationship with service offerings that signify higher quality and value in order to maximize customer referrals

    The Grizzly, February 12, 1988

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    Harassment Runs Rampant • Security Tips for Safe Driving • Tapping the Task Force • Schroeder for Press • Sex Still Religiously Private • Letter: Commencing the Issue • Restructuring the Ursinus Tradition: Task Force Transcends Past Goals • Speech Exam Announced • Participants Model the U.N. • Winner-Take-All in Ursinus-Moravian Showdown • Hoopsters Vastly Improved • Reckless Wrestlers Rustlin\u27 Victory • The Bigger Doesn\u27t Mean the Better • Beam Breakin\u27 Benner • \u27Mers Keep Victory Abreast • Conwell Cuts the Cake • Reflect: Success Promising • Dole Doles out Compromise • Can\u27t a Person Change His Mind? • Race for the White House: The Candidateshttps://digitalcommons.ursinus.edu/grizzlynews/1204/thumbnail.jp

    Elongation factor Tu is a multifunctional and processed moonlighting protein

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    Many bacterial moonlighting proteins were originally described in medically, agriculturally, and commercially important members of the low G + C Firmicutes. We show Elongation factor Tu (Ef-Tu) moonlights on the surface of the human pathogens Staphylococcus aureus (SaEf-Tu) and Mycoplasma pneumoniae (MpnEf-Tu), and the porcine pathogen Mycoplasma hyopneumoniae (MhpEf-Tu). Ef-Tu is also a target of multiple processing events on the cell surface and these were characterised using an N-terminomics pipeline. Recombinant MpnEf-Tu bound strongly to a diverse range of host molecules, and when bound to plasminogen, was able to convert plasminogen to plasmin in the presence of plasminogen activators. Fragments of Ef-Tu retain binding capabilities to host proteins. Bioinformatics and structural modelling studies indicate that the accumulation of positively charged amino acids in short linear motifs (SLiMs), and protein processing promote multifunctional behaviour. Codon bias engendered by an A + T rich genome may influence how positively-charged residues accumulate in SLiMs

    SOSIALISASI PENCEGAHAN STUNTING DAN TALKSHOW “SEDIKIT LEBIH BEDA LEBIH BAIK DARIPADA SEDIKIT LEBIH BAIK” DESA PARIT KECAMATAN CEMPAGA HULU KABUPATEN KOTAWARINGIN TIMUR

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    Kuliah Kerja Nyata merupakan salah satu program dan kegiatan dalam rangka menciptakan dan menumbuhkan jiwa pengabdian pada diri mahasiswa dengan menerapkan berbagai ilmu dan teori yang didapatkan dibangku perkuliahan sehingga dapat diterapkan dan bermanfaat khususnya bagi masyarakat pedesaan. Mahasiswa harus mampu memberikan kontribusi kepada desa untuk menuju desa yang mandiri dan berkelanjutan. Ada 4 sub tema yang sudah ditetapkan oleh Lembaga Penelitian dan Pengabdian Kepada Masyarakat kepada mahasiswa KKN-T Mandiri Edisi Khusus Tahun 2022. Salah satu implementasi dari sub tema tersebut adalah program kerja, sosialisasi pencegahan stunting dan talkshow “Sedikit Lebih Beda Lebih Baik Daripada Sedikit Lebih Baik” Desa Parit Kecamatan Cempaga Hulu Kabupaten Kotawaringin Timur. Tujuan dilaksanakannya Program kerja ini untuk menjadikan warga desa terutama para remaja menjadi lebih inovatif dan sehat serta membantu perangkat desa untuk memaksimalkan pelayanan kepada masyaraka
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